QLS seminar by Rati Sharma in person on 24 November 2022 at 11.00 CET

[Quantitative Life Sciences]

Dear All,

Tomorrow,  Thursday, 24 November at 11:00 CET, Rati Sharma (Indian 
Institute of Science Education and Research-IISER, Bhopal, India) will 
give a seminar titled:

*Stochasticity in cellular processes*

_Abstract:_
All cellular processes are characterized by stochasticity (or noise) and 
the kind of noise involved has profound effects on their dynamics. In 
this talk, I will discuss the effects of noise on two specific 
biological processes viz. (i) mRNA translation process and (ii) 
virus-immune response pathway.
In the first problem we model extrinsic noise in mRNA translation, and 
find, among other effects, the residence time distribution broadens 
significantly when the noise influences the entry rate (initiation rate 
of ribosome on the mRNA) in comparison to the exit rate of ribosomes. 
The ribosome residence time distribution obtained due to the presence of 
extrinsic noise in the translation initiation rate is also similar to 
that obtained for the natural codon specific variation of initiation 
rates [1].

In the second problem, I will discuss our model of the interaction 
between T cells (immune cells) and viruses. We introduced fractional 
Gaussian noise in order to account for variability in the dynamics of 
the entities and obtain an analytical expression for the joint 
probability density function of these variables and the average viral 
load in the early and late stages of infection [2]. In further 
extensions, we developed and studied a more complex model through 
simulations [3]. Upon comparing the theoretically predicted average 
virus levels to those of COVID-19 patients, we hypothesize that the long 
lived dynamics that are characteristic of such viral infections are due 
to the long range correlations in the temporal fluctuations of the virions.

The effects of noise on these specific cellular processes illustrate the 
importance of studying variability in these systems.


References:

     [1] Extrinsic noise effects on ribosomal traffic during the 
translation process. Rati Sharma*. J. Stat. Mech: Theory Exp. 053504 (2022).

     [2] A near analytic solution of a stochastic immune response model 
considering variability in virus and T cell dynamics. Abhilasha Batra 
and Rati Sharma*. J. Chem. Phys. 154, 195104 (2021).

     [3] Persistent correlation in cellular noise determines longevity 
of viral infections. Abhilasha Batra, Shoubhik Chandan Banerjee and Rati 
Sharma*. J. Phys. Chem. Lett. 13, 7252 (2022).

Indico webpage: https://indico.ictp.it/event/10140/

___The seminar will take place in the Common area, second floor, old 
SISSA building_

You are all most welcome to attend!

Best regards,
Erica

Erica Sarnataro
Group Secretary Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste, Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail: qls at ictp.it