QLS seminar "Multiscale Simulations for an affordable description of virus in motion: Symmetry-related dynamics determines ZIKA and Dengue neutralization" - 26 June 11h00

[Quantitative Life Sciences]

Dear All,

On Monday, 26 June  2023 at 11:00 CET, Sergio Pantano (nstitut Pasteur 
de Montevideo, Uruguay) will give a seminar titled:

*    Multiscale Simulations for an affordable description of virus in 
motion: Symmetry-related dynamics determines ZIKA and Dengue neutralization*

Abstract:
IMolecular dynamics simulation running simultaneous molecular 
granularities drastically reduce computational costs, making the study 
of whole viruses available to desktop computers. I will illustrate the 
use of a coarse-grained force field for biomolecules to perform a set of 
simulations on Zika, Dengue, and other related viruses. Comparative 
analysis among five common viruses pinpoints a collective variable that 
shows similar behavior only in the 3-fold symmetry axis of the 
icosahedral structure and coincides with the binding site of broadly 
neutralizing antibodies for Zika and Dengue.
Noteworthy, this dynamical similarity is only conserved in the same 
symmetry region of phylogenetically close viruses, suggesting an 
Achilles heel for crossed  neutralization of similar viruses.

_The seminar will take place in the *Fibonacci room*, Galileo guest 
house__, via Beirut, 7

_Indico webpage: https://indico.ictp.it/event/10410/


You are all most welcome to attend!

Best regards,
Erica

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail:qls at ictp.it