QUANTITATIVE LIFE SCIENCES GUEST SEMINAR - Monday, 13 May @ 14h00

[Quantitative Life Sciences]

QUANTITATIVE LIFE SCIENCES GUEST SEMINAR

Monday, 13 May 2019 at 14:00,
ICTP, Central Area, 2nd floor, old SISSA building, via Beirut 2

Speaker: Kunihiko Kaneko - Universal Biology Institute, University of 
Tokyo,

Title:  Universal Biology in Adaptation and Evolution: Multilevel 
Consistency, Dimension Reduction, and Fluctuation-Response Relationship

Abstract:
A macroscopic theory for cellular states with steady-growth is 
presented, based on consistency between cellular growth and molecular 
replication, as well as robustness of phenotypes against perturbations. 
Adaptive changes in high-dimensional phenotypes are shown to be 
restricted within a low-dimensional slow manifold, from which a 
macroscopic law for cellular-states is derived, as is confirmed by 
adaptation experiments of bacteria under stress. Next, the theory is 
extended to phenotypic evolution, leading to proportionality between 
phenotypic responses against genetic evolution and by environmental 
adaptation.  Evolutionary relevance of slow modes in controlling 
high-dimensional phenotypes is discussed. Last, if I have time, 
transition from exponential-growth to stationary phases is investigated 
as the breakdown of steady-growth.  A general law between the starvation 
time and lag-time to recover the cellular growth is discussed.

   Indico web page: http://indico.ictp.it/event/8945/

Everyone interested is most welcome to attend!

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail: qls at ictp.it