QLS Guest Seminar - 11 January

[Quantitative Life Sciences]

QUANTITATIVE LIFE SCIENCES  GUEST SEMINAR

Thursday, 11 January 2018 at 11:00,
ICTP, Central Area, 2nd floor, old SISSA building


Speaker: Tetsuya J. Kobayashi - Institute of Industrial Science, 
University of Tokyo

Title: Fitness response relation of growing population:  an application 
of large deviation theory and semi-Markov processes

Abstract:
Fitness is a macroscopic quantity that characterizes the potential 
success of a growing population of organisms and cells.
Fitness is also a major target or objective for controlling growth and 
expansion of pathological bacteria and tumors by perturbing properties 
of individual cells such as replication rate, death rate and so on.
Better understanding of the nature of growing populations and the 
controllability over them requires us to clarify the relation how the 
fitness is determined by these single-cell or single-organism level 
properties.
To this end, we investigate a multi-type age-structured population model 
in which the inter-division interval and phenotypic states of cells are 
accounted.
By using a path integral formulation of the model and its contraction 
onto the pairwise empirical quantities, we derive a response relation of 
the fitness to the change in the several single-cell-level parameters.
This work is an extension of our previous work with Dr. Yuki Sughiyama [1].

[1] Y. Sughiyama, T.J. Kobayashi, et al., Pathwise thermodynamic 
structure in population dynamics, Phys. Rev. E. 2015.


Indico web page: http://indico.ictp.it/event/8481/


Everyone interested is most welcome to attend!

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail: qls at ictp.it