SPECIAL SEMINAR on Statistical Physics

[CM ICTP - Trieste]

CONDENSED MATTER AND STATISTICAL PHYSICS SECTION

	
SPECIAL SEMINAR  on  Statistical Physics





Tuesday, 20 November    -    2:30 p.m.



Room C - Main Building Terrace Level


		


A. SAMAL
( University of Delhi )



" System level dynamics and robustness of the genetic network 
regulating E.coli metabolism "



Abstract
In this talk, I will present some of the results obtained by studying 
the large scale transcriptional regulatory network controlling E. coli 
metabolism containing 583 genes and 96 external metabolites as a 
Boolean dynamical system. We have studied how the attractors of the 
boolean dynamical system depend on the initial condition of the genes 
and on various environmental conditions. We find that the nature of the 
attractors endows the cell with both stability for a fixed environment 
and flexibility to adapt to changes in the environment. We comment on 
design features of the system that are responsible for these observed 
system level properties. In particular, I will reflect upon our results 
obtained by studying this real genetic network as opposed to those 
obtained earlier by studying random boolean networks.