CMSP Seminar (Atomistic Simulation Seminar Series) 25 September, 11:00hrs, by M. M. Wisman Acharige

[CMSP Seminars Secretariat]

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CMSP Seminar (Atomistic Simulation Seminar Series)
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*Wednesday, 25 September 2024, 11:00 hrs*
*/Luigi Stasi Seminar Room (Leonardo Building, first floor)/*/
/
/Zoom registration link: 
https://zoom.us/meeting/register/tJIqf-ihrzkqH9AgyozbVO89Im32vIxe3ubZ<https://zoom.us/meeting/register/tJYqfuiorD0sGNCx1kyeA8kWzKVCHsOitCwN>
<https://zoom.us/meeting/register/tJIqf-ihrzkqH9AgyozbVO89Im32vIxe3ubZ> /

Speaker:*  Monika Madhavi Wisman Acharige * (University of Colombo, Sri 
Lanka)

Title: *Molecular Origin of the Phenomenal Properties of Hydrated Collagen *

Abstract:
Collagen is the most abundant protein in the human body and plays a 
major role in the function of many tissues such as cartilage, tendon and 
ligament. Therefore, the structure-property-function relationships in 
collagen are key to understanding health and disease and developing 
collagen- based materials for medical purposes.
Nuclear Magnetic Resonance spin relaxation of water protons is a useful 
marker of the microstructure and composition of biological tissues. 
Proton spin relaxation is determined by intra and intermolecular 
interactions of spins with the magnetic moments of neighbouring nuclei. 
The interactions are mediated by the dynamics of the water molecules, 
which depend on the composition and cellular organization of the tissue. 
In partially aligned tissues such as tendon, relaxation rates depend on 
the orientation of the tissue relative to the applied magnetic field. 
This dependence (termed as the magic-angle effect) can be used to probe 
the microscopic 3D architecture of the tissue and inform the 
interpretation of MRI studies of cartilage biomechanics. Despite many 
experimental and computational studies conducted, microscopic origin of 
the magic angle effect is still not completely understood.
In this presentation we will discuss our approach in investigating the 
molecular origin of the magic angle effect, current results and future 
implications.


http://www.ictp.it/research/cmsp.aspx

The Abdus Salam International Centre for Theoretical Physics
https://www.ictp.it/

    
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