THIS WEEK - 2 QLS SEMINARS - Tue, 9 and Fri, 12 May

[Quantitative Life Sciences]

Dear All,

The QLS Section wil host TWO SEMINARS this week, to be held in the L. 
Stasi seminar room (Leonardo building). Please find below all details:


On Tuesday, 9 May 2023 at 11:00 CET, Marcelo Kuperman (Centro Atomico 
Bariloche-Instituto Balseiro, S.C. de Bariloche, Argentina) will give a 
seminar titled:
*
Analyzing Football as a Complex System*

Abstract:

In this talk, we present a study on the dynamics of marking in football 
matches. To do this, we survey and analyze a database containing the 
trajectories of players from both teams on the field of play during 
three professional
games. We describe the dynamics through the construction of temporal 
bipartite networks of proximity. Based on the introduced concept of 
proximity, the nodes are the players, and the links are defined between 
opponents that
are close enough to each other at a given moment. By studying the 
evolution of the heterogeneity parameter of the networks during the 
game, we characterize a scaling law for the average shape of the 
fluctuations, unveiling
the emergence of complexity in the system. Moreover, we propose a simple 
model to simulate the players’ motion in the field from where we 
obtained the evolution of a synthetic proximity network. We show that the
model captures with a remarkable agreement the complexity of the 
empirical case, hence it proves to be helpful to elucidate the 
underlying mechanisms responsible for the observed phenomena.
___
_Indico webpage: https://indico.ictp.it/event/10354/

*************************************************************************************************************************************************************************************************************************************************************

On Friday, 12 May 2023 at 9:00 CET, Diego M. Bustos (CONICET, FCEN 
UNCuyo, Lab Integración de Señales Celulares, Mendoza, Argentina) will 
give a seminar titled:
*
Discovery of 14-3-3 protein allosterisms by molecular dynamics *

Abstract:
Molecular dynamics techniques can help unravel the functions of 
biomolecules in many ways. In this talk, I will describe how we 
discovered a completely new allosteric binding site in a protein family 
called 14-3-3. This protein family is involved in a fundamental 
mechanism of protein phosphorylation, a mechanism used in eukaryotic 
cells to activate or inactivate thousands of proteins.
Using molecular dynamics, we were able to discover the allosteric site, 
find and improve an active agent for this site, and describe the 
subsequent step after binding to the final conformational change in 
14-3-3 that closes (and inactivates) the protein.
___
_Indico webpage: https://indico.ictp.it/event/10357/




___The seminars will take place in the L. Stasi seminar room, first 
floor, Leonardo building__

_You are all most welcome to attend!

Best regards,
Erica

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail:qls at ictp.it