QLS seminar by Diego M. Bustos - 12 May 2023 at 9:00 CET

[Quantitative Life Sciences]

Dear All,

On Friday, 12 May 2023 at 9:00 CET, Diego M. Bustos (CONICET, FCEN 
UNCuyo Lab Integración de Señales Celulares, Mendoza, Argentina) will 
give a seminar titled:
*
Discovery of 14-3-3 protein allosterisms by molecular dynamics *

Abstract:
Molecular dynamics techniques can help unravel the functions of 
biomolecules in many ways. In this talk, I will describe how we 
discovered a completely new allosteric binding site in a protein family 
called 14-3-3. This protein family is involved in a fundamental 
mechanism of protein phosphorylation, a mechanism used in eukaryotic 
cells to activate or inactivate thousands of proteins.
Using molecular dynamics, we were able to discover the allosteric site, 
find and improve an active agent for this site, and describe the 
subsequent step after binding to the final conformational change in 
14-3-3 that closes (and inactivates) the protein.
___
__The seminar will take place in the L. Stasi seminar room, first floor, 
Leonardo building__

_Indico webpage: https://indico.ictp.it/event/10357/

You are all most welcome to attend!

Best regards,
Erica

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail:qls at ictp.it