QLS seminar (Sudipto Muhuri) in person on 5 July 2022 at 14.00 CET

[Quantitative Life Sciences]

Dear All,

Tomorrow,  Tuesday, 5 July  2022  at 14:00 CET, Sudipto Muhuri (Dept. of 
Physics, Savitribai Phule Pune University, India) will give a seminar titled

*Novel mechanism for oscillations in catchbonded motor-filament complexes*


Abstract:
Catchbonding, characterized by the increase of the molecular bond 
lifetime in response to applied forces is observed for biological 
macromolecules, including motor proteins within cells. Hitherto, the 
primary biological functional role of catchbonding was thought to be 
that of improving adhesion properties of cells to surfaces when subject 
to tensile forces. However, our study reveals that allosteric 
deformations in dynein motors, which lead to the catchbonding, can also 
manifest as a generic mechanism to generate spontaneous mechanical 
oscillations in motor-cytoskeletal filament complexes. The resultant 
phase diagram of such motor-filament systems, characterized by 
force-induced allosteric deformations exhibits bistability and sustained 
limit-cycle oscillations in biologically relevant regimes, such as for 
catchbonded dynein. The results elucidate the central role of this 
mechanism in fashioning a distinctive stability behavior and 
oscillations in motor-filament complexes such as mitotic spindles. In 
essence, this study uncovers a crucial functional role of the biological 
catchbonding in intracellular processes ranging from spindle 
oscillations during cell division to intracellular transport.

Reference:
Biophys. J, 120, 4129 (2021)

The seminar will be held in the *Common area, second floor, ex SISSA 
building, *via Beirut, 2.

You are all most cordially invited to attend

Best regards,

Erica


-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
www.ictp.it/research/qls.aspx
e-mail:qls at ictp.it