QLS Guest Seminar - Thursday 19 May

[Quantitative Life Sciences]

QUANTITATIVE LIFE SCIENCES GUEST SEMINAR

Thursday, 19 May at 14:00

ICTP, Central Area, 2nd floor, old SISSA building

Speaker: Abdo Abdo Abdellah Elfiky - Faculty of Science, Department of 
Biophysics, Cairo University, Egypt


Title: " Viral Proteins Inhibition via Computer-Aided Drug Design"

Abstract:
Hepatitis C Virus (HCV) is a widely spread viral infection that affects 
millions of people worldwide. Liver cirrhosis and Hepatocellular 
Carcinoma have very strong link to liver viruses B and C. Sofosbuvir is 
a newly FDA approved drug (Dec. 2013) that acts against the spread of 
HCV. It is a Non-Structural 5B (NS5B) RNA dependent RNA polymerase 
(RdRp) Nucleoside Inhibitors (NI). Sofosbuvir is an anti-HCV drug among 
different compounds (e.g. IDX-184, R7128, etc.) that were under clinical 
trials for years.

The lecture aims at providing a deep insight on the utilization of 
molecular modeling in conjunction with Quantitative Structure–Activity 
Relationship (QSAR) in studying the interaction between activated drugs 
and 12 amino acids constituting a 5 Å region surrounding the conserved 
active site motif GDD of HCV. These studies among many other studies on 
MERS CoV and Zika virus proteins would accelerate the rate of antiviral 
approval in pharmaceutical research and development.

Web page: http://indico.ictp.it/event/7882/

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
e-mail: qls at ictp.it