Quantitative Life Sciences GUEST SEMINAR - Tuesday 12 July

[Quantitative Life Sciences]

QUANTITATIVE LIFE SCIENCES GUEST SEMINAR

Tuesday 12 July at 11:00

ICTP, Central Area, 2nd floor, old SISSA building

Speaker: Carla Bosia - Human Genetics Foundation Torino, Turin, Italy

Title: "RNAs competing for microRNAs mutually influence their 
fluctuations in a microRNA-dependent manner"

Abstract:
Distinct RNA species may compete for binding microRNAs, a class of small 
non-coding transcripts involved in post-transcriptional downregulation. 
This competition creates an indirect interaction between microRNA 
targets that behave as microRNA sponges and eventually influence each 
other expression levels. Theoretical predictions suggest that not only 
the mean target expression levels but also the fluctuations around the 
means are coupled through microRNAs, potentially resulting in even more 
striking effects on a broad range of cellular processes. With an 
experimental design based on two bidirectional plasmids and flow 
cytometry measurements of cotransfected mammalian cells, we validated a 
stochastic gene interaction model that describes how mRNAs can influence 
each other’s fluctuations in a microRNA-dependent manner in single cells.

Indico web page: http://indico.ictp.it/event/7909/

-- 
Erica Sarnataro
Group Secretary
Quantitative Life Sciences
The Abdus Salam International Centre for Theoretical Physics (ICTP)
Trieste,  Italy
Tel. +39-040-2240623
e-mail:qls at ictp.it