MathLab seminar announcement

[Emanuele Tuillier Illingworth]

MATHLAB SEMINAR ANNOUNCEMENT
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Date: Tuesday, 1 December, 2015 - 14:30

Speaker: Alessio Gizzi (LIUCBM - Libera Università Campo Bio-Medico di Roma)

Room: SISSA - Santorio A - room 133

Abstract:
  In vitro models usually fail to recapitulate the complex organization 
of multicellular environments. Innovative robust platforms based on 
cells-on-chip technologies, instead, replicate the main functions of the 
target organ. The present contribution will describe advanced 
micro-fabricated fluidic PDMS membrane devices, purposely designed as a 
platform for mechanical and chemical sensors for cells and tissues as 
well as for human safety testing. The bio-micro interface allows to 
study cellular mechanics in both static and dynamic environments. In 
particular, a novel dedicated multi-axial design is introduced. A 
special focus will be given to the integration of the physical platform 
with in silico modeling tools, for a consistent analysis and the 
extraction of informative data. As representative example of advancement 
with respect to available technologies, a gut-on-chip protocol will be 
described in terms of: i) a multilayer cell culture and the presence of 
gut microflora; ii) permeability toward different chemical compounds; 
iii) the application of mechanical stretching to the cell layers through 
chip micro-actuation. The present technology is compatible with time 
lapse microscopy for high throughput screening and with standard 
chemical, biochemical, and molecular biology analyses to be performed on 
supernatants and/or cells.