CBM seminar - 6th December - h 11.00 AM

[Maria Teresa]

Dear All,

You are kindly invited at CBM seminar:



DNA, Protein and Quantum Dot Conjugates as Powerful Tools in  
Bionanotechnology

Dr. Ljiljana Fruk - Universität Dortmund - FB Chemie, Biologisch- 
Chemische Mikrostrukturtechnik - Germany



Thursday, 6th December 2007, 11.00 AM


Conference Room CBM - Q Building - 1st floor

AREA Science Park, Basovizza, Trieste


Today there is a great interest in developing technologies to  
precisely organise and integrate proteins into highly ordered micro-  
and nanostructured assemblies. One approach to achieve this goal is  
the use of DNA directed immobilisation ( DDI) which makes use of the  
specificity of DNA base pairing to anchor protein to surfaces of  
planar substrates or nanoparticles and offers many advantages over  
conventional immobilization methods. Covalent heme-DNA adducts can be  
used to prepare semisynthetic DNA- heme enyzme conjugates containing  
DNA oligomers coupled in close proximity to the active site. Such  
conjugates show remarkable kinetic activity and are capable of  
specific binding to a solid supports containing capture DNA probes.  
The programmable binding properties enabled by DNA hybridisation make  
such semisynthetic enyzmes useful for a broad range of applications,  
particulary in biocatalysis, electrochemical sensing and as building  
blocks in biomaterial design. In addition heme enyzmes, which play a  
key role in numerous applications in the field of biocatalysis and  
bioanalyitics can be coupled to quantum dots (QD) nanoparticles and  
their activity reversibly switched on an off by photoirradiation.  
Four different peroxidases were successfully activated using this QD- 
irradiation methodology which is anticipated to prove very useful in  
biosensing, biocatalysis and design of novel cellular assay procedures.


For information: CBM - tel. 040 375 7711 - info at cbm.fvg.it


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