SEMINAR @ SISSA, Trinh Xuan Hoang 31/03/06

[Barbara Corzani]

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STATISTICAL AND BIOLOGICAL PHYSICS SEMINAR
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Prof. Trinh Xuan Hoang
Institute of Physics and Electronics 
Vietnamese Academy of Science and Technology

Title:
"Structure selection in protein folding: perspectives from the tube-like 
model"

Friday  31  Mar. 2006  @ 11.00 a.m.


SISSA - Basement floor - room A

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Abstract:

We present the simple coarse-grained model which demonstrates that the 
native folds of proteins can emerge on the basis of their common 
attributes. These are the inherent anisotropy of the chain molecule, the 
geometrical and energetical constraints imposed by hydrogen bonding, 
sterics and hydrophobicity. Our study of homopolymers points to a 
hypothesis that protein structures lie in a marginally compact phase in 
which the free energy landscape is pre-sculpted by geometry and symmetry. 
We elucidate the key role played by sequence design in selecting the 
structure of choice from the predetermined menu of putative native state 
structures, and the tendency of many chains to form amyloid aggregates
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